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Zoloft is the brand name. Sertraline is the generic name. Zoloft is a selective serotonin reuptake inhibitor (SSRI) used to treat depression and other disorders. SSRI medications affect the levels of serotonin in the brain. For many people, these medications are the first choice for the treatment of depression.

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Weight Loss: Significant weight loss may be an undesirable result of treatment with sertraline for some patients, but on average, patients in controlled trials had minimal, 1 to 2 pound weight loss, versus smaller changes on placebo. Only rarely have sertraline patients been discontinued for weight loss.

Seizure: Zoloft has not been evaluated in patients with a seizure disorder. These patients were excluded from clinical studies during the product’s premarket testing. No seizures were observed among approximately 3000 patients treated with Zoloft in the development program for depression. However, 4 patients out of approximately 1800 (220 <18 years of age) exposed during the development program for obsessive-compulsive disorder experienced seizures, representing a crude incidence of 0.2%. Accordingly, Zoloft should be introduced with care in patients with a seizure disorder.

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  • February 23, 2008
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